Whitney Houston, whose soaring voice lifted her to the top of the pop music world but whose personal decline was fueled by years of drug use, died on Saturday afternoon in a Beverly Hills hotel room. She was 48.

Houston’s publicist, Kristen Foster, said Saturday that the singer had died, but the cause and the location of her death were unknown.

News of Houston’s death came on the eve of music’s biggest night – the Grammy Awards. It’s a showcase where she once reigned, and her death was sure to cast a heavy pall on Sunday’s ceremony. Houston’s longtime mentor Clive Davis was to hold his annual concert and dinner Saturday; it was unclear if it was going to go forward.

“I am absolutely heartbroken at the news of Whitney’s passing,” music producer Quincy Jones said in a written statement. “I always regretted not having had the opportunity to work with her. She was a true original and a talent beyond compare. I will miss her terribly.”

At her peak, Houston was the golden girl of the music industry. From the middle 1980s to the late 1990s, she was one of the world’s best-selling artists. She wowed audiences with effortless, powerful, and peerless vocals that were rooted in the black church but made palatable to the masses with a pop sheen.

Her success carried her beyond music to movies, where she starred in hits like “The Bodyguard” and “Waiting to Exhale.”

She had the perfect voice, a gorgeous singer who had sex appeal but was never overtly sexual, who maintained perfect poise.

She influenced a generation of younger singers, from Christina Aguilera to Mariah Carey, who when she first came out sounded so much like Houston that many thought it was Houston.

Rest in peace, Whitney.